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In some embodiments, the otoprotectant is a compound of Formula (XI): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4

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This was also demonstrated in a study on two types of mice: C57Bl/6 mice, who had low levels of enkephalinase, and BALB/c mice, who had high levels of enkephalinase

Epithalon, upon delivery, appeared to inhibit the process of metastasis in the mice, preventing tumor cell cycle and growth

We cant apply the findings to humans due to different metabolism and physiology